

Acute myeloid leukaemia complicated by anergic tuberculosis. CD4+ T Cells Contain Early Extrapulmonary Tuberculosis (TB) Dissemination and Rapid TB Progression and Sustain Multieffector Functions of CD8+ T and CD3- Lymphocytes: Mechanisms of CD4+ T Cell Immunity.

Fatal mycobacteremia caused by Mycobacterium tuberculosis in a patient with acute leukemia. Hodgkin disease associates with tuberculosis of unusual presentation.

Patients with LPD are a group at increased risk for tuberculosis. If the chemotherapy of LPD was effective, tuberculosis was cured in all the patients. When tuberculosis and LPD were simultaneously found, both diseases were concurrently treated. Tuberculosis was detected in 43% of the patients with HL in remission it occurred only in other hemoblastoses in its active phase. In pulmonary tuberculosis, its disseminated and focal involvements were found in 71 and 18% of cases, respectively. In accordance with its site, pulmonary tuberculosis was 73% extrapulmonary tuberculosis, 14% generalized tuberculosis, 12%. According to the nosological entity, the tuberculosis detection rates were 3% (40/1350) in Hodgkin lymphoma (HL), 1.2% (20/1627) in aggressive lymphomas, 1.4% (16/1136) in mature cell lymphomas and chronic lymphocytic leukemia, and 2.9% (9/309) in hairy cell leukemia. Tuberculosis was identified in 85 (2%) patients with LPD. Tuberculosis was verified by the results of a comprehensive examination involving the histological study of biopsy specimens. Lymphomas and leukemias were diagnosed using the universally protocols. In 1990 to 2013, the Hematology Research Center, Ministry of Health of Russia, followed up 4422 patients with LPD. To study the clinical manifestations, diagnosis, and treatment of lymphoproliferative diseases (LPD) concurrent with tuberculosis.
